2020 Grant Awards

Joslin Diabetes Center

Principal Investigator: Cristina Aguayo-Mazzucato, MD, PhD
Project Title: Molecular Progression of Senescence and Generation of a SASP Signature in B-Cells

University of Kansas Medical Center Research Institute

Principal Investigator: Mary A. Markiewicz, PhD
Project Title: The Mechanism of Autoimmune Diabetes Protection Mediated by NKG2D-Induced GD8+Tcm

Joslin Diabetes Center

Principal Investigator: Mary Elizabeth Patti, MD
Project Title: The impact of Type 1 DM and Glycemic Control on Epigenetic Marks on Male Germ Cells

City of Hope National Medical Center

Principal Investigator: Defu Zeng, MD
Project Title: B Cell Regeneration in Established/Long-Standing Autoimmune Diabetic NOD Mice

University of California San Francisco

Principal Investigator: Matthias Hebrok, PhD
Project Title: The Role of BOLA3 in Beta Cell Function

University of California San Francisco

Principal Investigator: Julie B. Sneddon, PhD
Project Title: Engineering a Cellular Niche for Transplantation of Human Stem Cell-Derived Beta Cells

2019 Grant Awards

Joslin Diabetes Center

Principal Investigator: Peng Yi, PhD
Project Title: A whole genome CRISPR screen looking for factors that regulate beta cell neogenesis from pancreatic duct cells.

University of California San Francisco

Principal Investigator: Audrey V. Parent, PhD
Project Title: Immunoengineering of stem cell-derived insulin-producing cells for cell therapy and disease modeling.

University of Colorado Barbara Davis Center for Childhood Diabetes

Principal Investigator: Howard W. Davidson, PhD
Project Title: Immune changes in the honeymoon period at the single cell level.

Vanderbilt University Medical Center

Principal Investigator: Daniel Moore, MD, PhD
Project Title: How B Lymphocytes Prevent Transplantation Tolerance in T1D.

Joslin Diabetes Center

Principal Investigator: Rohit Kulkarni, MD, PhD
Project Title: Evaluating the therapeutic significance of SerpenB1 in T1D – a proof-of-concept proposal.

University of Michigan

Principal Investigator: Patrice Fort, PhD
Project Title: Inflammation in the diabetic human retina – role in disease progression.

Joslin Diabetes Center *

Principal Investigator: Aleksander Kostic, PhD
Project Title: Identifying T Cell Dynamics predictive of Type 1 Diabetes Immunopathogenesis.

Joslin Diabetes Center *

Principal Investigator: Monika Niewczas, MD, PhD, MPH.
Project Title: Complement Proteome and High Risk of Kidney Failure in Type 1 Diabetes

Brigham Young University *

Principal Investigator: Jeffery S. Tessem, PhD
Project Title: Defining beta cell heterogeneity to expand functional beta cell mass as a treatment for Type 1 Diabetes
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(*) Funding provided by the Thomas J. Beatson, Jr. Foundation Trust, a second charitable foundation established by Thomas J. Beatson, Jr. during his lifetime.