(*) Funding provided by the Thomas J. Beatson, Jr. Foundation Trust, a second charitable foundation established by Thomas J. Beatson, Jr. during his lifetime.
2022 Grant Awards
UCLA Medical Center-Lundquist Institute
Principal Investigator: Eiji Yoshihara, PhD
Project Title: Proliferative Functional Human Islet-Like Organoids
Project Title: Proliferative Functional Human Islet-Like Organoids
Joslin Diabetes Center
Principal Investigator: Thomas Serwold, PhD
Project Title: Establishing Immune Tolerance to Engrafted Beta Cells With 5-Module CARs
Project Title: Establishing Immune Tolerance to Engrafted Beta Cells With 5-Module CARs
Washington University
Principal Investigator: Jeffrey R. Millman, PhD
Project Title: Deciphering Differentiation to Insulin-Secreting Islets for Diabetes Cellular Therapy
Project Title: Deciphering Differentiation to Insulin-Secreting Islets for Diabetes Cellular Therapy
University of Colorado-Denver
Principal Investigator: Rachel S. Friedman, PhD
Project Title: Harnessing Myeloid Cell Mechanisms of Islet Protection
Project Title: Harnessing Myeloid Cell Mechanisms of Islet Protection
Joslin Diabetes Center
Principal Investigator: Jean Schaffer, MD
Project Title: β-Cell Ribosome Adaptations for Insulin Productions
Project Title: β-Cell Ribosome Adaptations for Insulin Productions
2021 Grant Awards
Columbia University
Principal Investigator: Remi J. Creusot, PhD
Project Title: : A Novel mRNA Vaccine
for Type 1 Diabetes
Project Title: : A Novel mRNA Vaccine
for Type 1 Diabetes
Joslin Diabetes Center
Principal Investigator: Sarah Lessard, MSc, PhD
Project Title: : Identifying Therapeutic Targets to Improve Aerobic Capacity in People With T1D
Project Title: : Identifying Therapeutic Targets to Improve Aerobic Capacity in People With T1D
University of California, San Francisco
Principal Investigator: Qizhi Tang, PhD
Project Title: Fortify Tregs to Restore Immune Tolerance in Autoimmune Diabetes
Project Title: Fortify Tregs to Restore Immune Tolerance in Autoimmune Diabetes
Columbia University
Principal Investigator: Xiojuan Chen, MD, PhD
Project Title: Regulating Human α- and δ- Cell Function in Pseudo-T1D Islets
Project Title: Regulating Human α- and δ- Cell Function in Pseudo-T1D Islets
Joslin Diabetes Center
Principal Investigator: Stephan Kissler, PhD
Project Title: Designing a Novel Drug to Protect Beta Cells Against Autoimmunity
Project Title: Designing a Novel Drug to Protect Beta Cells Against Autoimmunity
University of Texas at Austin
Principal Investigator: John (Jack) Virostko, PhD, MSCI
Project Title: Machine Learning of MRI of the Pancreas in T1D and Application to Hispanic Population
Project Title: Machine Learning of MRI of the Pancreas in T1D and Application to Hispanic Population
Joslin Diabetes Center
Principal Investigator: Elena Toschi, PhD
Project Title: Evaluating the Use of Telehealth and Diabetes-Related Technologies in Older Adults With Type 1 Diabetes
Project Title: Evaluating the Use of Telehealth and Diabetes-Related Technologies in Older Adults With Type 1 Diabetes
University of California, San Francisco
Principal Investigator: Gregory M. KU, MD, PhD
Project Title: Whole Genome CRISPR Screens in Primary Human Pancreatic Beta Cells to Identify New Regulators of Survival and Proliferation
Project Title: Whole Genome CRISPR Screens in Primary Human Pancreatic Beta Cells to Identify New Regulators of Survival and Proliferation
2020 Grant Awards
Joslin Diabetes Center
Principal Investigator: Cristina Aguayo-Mazzucato, MD, PhD
Project Title: Molecular Progression of Senescence and Generation of a SASP Signature in B-Cells
Project Title: Molecular Progression of Senescence and Generation of a SASP Signature in B-Cells
University of Kansas Medical Center Research Institute
Principal Investigator: Mary A. Markiewicz, PhD
Project Title: The Mechanism of Autoimmune Diabetes Protection Mediated by NKG2D-Induced GD8+Tcm
Project Title: The Mechanism of Autoimmune Diabetes Protection Mediated by NKG2D-Induced GD8+Tcm
Joslin Diabetes Center
Principal Investigator: Mary Elizabeth Patti, MD
Project Title: The impact of Type 1 DM and Glycemic Control on Epigenetic Marks on Male Germ Cells
Project Title: The impact of Type 1 DM and Glycemic Control on Epigenetic Marks on Male Germ Cells
City of Hope National Medical Center
Principal Investigator: Defu Zeng, MD
Project Title: B Cell Regeneration in Established/Long-Standing Autoimmune Diabetic NOD Mice
Project Title: B Cell Regeneration in Established/Long-Standing Autoimmune Diabetic NOD Mice
University of California San Francisco
Principal Investigator: Matthias Hebrok, PhD
Project Title: The Role of BOLA3 in Beta Cell Function
Project Title: The Role of BOLA3 in Beta Cell Function
University of California San Francisco
Principal Investigator: Julie B. Sneddon, PhD
Project Title: Engineering a Cellular Niche for Transplantation of Human Stem Cell-Derived Beta Cells
Project Title: Engineering a Cellular Niche for Transplantation of Human Stem Cell-Derived Beta Cells
2019 Grant Awards
Joslin Diabetes Center
Principal Investigator: Peng Yi, PhD
Project Title: A whole genome CRISPR screen looking for factors that regulate beta cell neogenesis from pancreatic duct cells.
Project Title: A whole genome CRISPR screen looking for factors that regulate beta cell neogenesis from pancreatic duct cells.
University of California San Francisco
Principal Investigator: Audrey V. Parent, PhD
Project Title: Immunoengineering of stem cell-derived insulin-producing cells for cell therapy and disease modeling.
Project Title: Immunoengineering of stem cell-derived insulin-producing cells for cell therapy and disease modeling.
University of Colorado Barbara Davis Center for Childhood Diabetes
Principal Investigator: Howard W. Davidson, PhD
Project Title: Immune changes in the honeymoon period at the single cell level.
Project Title: Immune changes in the honeymoon period at the single cell level.
Vanderbilt University Medical Center
Principal Investigator: Daniel Moore, MD, PhD
Project Title: How B Lymphocytes Prevent Transplantation Tolerance in T1D.
Project Title: How B Lymphocytes Prevent Transplantation Tolerance in T1D.
Joslin Diabetes Center
Principal Investigator: Rohit Kulkarni, MD, PhD
Project Title: Evaluating the therapeutic significance of SerpenB1 in T1D – a proof-of-concept proposal.
Project Title: Evaluating the therapeutic significance of SerpenB1 in T1D – a proof-of-concept proposal.
University of Michigan
Principal Investigator: Patrice Fort, PhD
Project Title: Inflammation in the diabetic human retina – role in disease progression.
Project Title: Inflammation in the diabetic human retina – role in disease progression.
Joslin Diabetes Center *
Principal Investigator: Aleksander Kostic, PhD
Project Title: Identifying T Cell Dynamics predictive of Type 1 Diabetes Immunopathogenesis.
Project Title: Identifying T Cell Dynamics predictive of Type 1 Diabetes Immunopathogenesis.
Joslin Diabetes Center *
Principal Investigator: Monika Niewczas, MD, PhD, MPH.
Project Title: Complement Proteome and High Risk of Kidney Failure in Type 1 Diabetes
Project Title: Complement Proteome and High Risk of Kidney Failure in Type 1 Diabetes
Brigham Young University *
Principal Investigator: Jeffery S. Tessem, PhD
Project Title: Defining beta cell heterogeneity to expand functional beta cell mass as a treatment for Type 1 Diabetes
Project Title: Defining beta cell heterogeneity to expand functional beta cell mass as a treatment for Type 1 Diabetes